Hereditary cancer risk can be determined by genetic testing

Heredity of cancer

In general, cancer is not hereditary, but it is estimated that about 5 to 10 percent of cancers are due to a hereditary predisposition to cancer. Hereditary cancer is suspected if

• more than one family members get cancer
• a person develops cancer at a particularly young age or
• a person develops several different cancers.

Rare inherited forms are known from almost all cancers. Most commonly found in hereditary susceptibility to breast and ovarian cancer as well as colon cancer.

How is a genetic test for hereditary cancer risk performed?

The test is done on a blood sample and you will get the results within five weeks. The sample is analyzed by the Finnish genetic testing laboratory Blueprint Genetics (FINAS and CAP accreditations, CE-marked tests). Blueprint Genetics uses the latest, state-of-the-art gene sequencing technology in testing, and the test results are interpreted by experienced geneticists. You will also meet with our hereditary doctor either before sampling or after the results of the genetic test will arrive.

The most typical genetic test for testing for hereditary cancer is the Hereditary Cancer High Risk gene panel, which analyzes a group of genes whose changes are known to predispose to hereditary cancer.

What does a genetic test say?

Genetic testing is a quick way to determine your hereditary cancer risk, but the cancer itself is not found on genetic testing. By identifying the hereditary risk factors for cancer, you are more alert and can lower your risk of cancer with your lifestyle or possible treatment measures.

A positive test result indicates an increased risk of developing cancer. The result provides additional information about the likelihood of becoming ill and provides information about the need for testing of other family members. You can make lifestyle choices, be more active in monitoring, or consider preventative treatment measures. At Docrates Cancer Center, it is possible for you to customize your personal follow-up program.

A negative test result means that no changes have been found in your genome that are known to predispose to cancer. However, in addition to hereditary factors, other factors such as general health, lifestyle and environmental factors also affect cancer risk. A negative test result therefore does not rule out the possibility of developing cancer. If you have a high incidence of cancer in your family, you may be at a higher risk of developing (a particular) cancer, even if the test is negative, because not all the genetic changes associated with cancer susceptibility are yet known.

An uncertain test result means that a genetic change has been found, but there is not enough information about its link to hereditary cancer. There are many harmless changes in the human genome that do not necessarily cause any harm to health. Our knowledge of genes is still limited, meaning that there may not yet be enough information about the link between a particular genetic change and hereditary cancer.

If your hereditary risk of developing cancer is a concern, please don’t hesitate to contact us and ask more +358 10 773 2010.